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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1975 1
1977 1
1980 1
1981 1
1982 1
1983 1
1985 2
1987 3
1988 1
1989 7
1990 2
1991 6
1992 4
1993 2
1994 2
1995 2
1996 1
1997 5
1998 1
1999 8
2000 6
2001 3
2002 6
2003 7
2004 10
2005 10
2006 13
2007 10
2008 7
2009 14
2010 13
2011 15
2012 14
2013 13
2014 17
2015 18
2016 19
2017 26
2018 22
2019 21
2020 23
2021 20
2022 16
2023 25
2024 9

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374 results

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Page 1
Comparison of middle- and bottom-up mass spectrometry in forced degradation studies of bevacizumab and infliximab.
Dyck YFK, Rehm D, Winkler K, Sandig V, Jabs W, Parr MK. Dyck YFK, et al. J Pharm Biomed Anal. 2023 Oct 25;235:115596. doi: 10.1016/j.jpba.2023.115596. Epub 2023 Jul 22. J Pharm Biomed Anal. 2023. PMID: 37540995 Review.
In this study the middle-up approach is compared to the more expensive bottom-up analysis in a forced oxidation biosimilar comparability study. Bevacizumab and infliximab as well as biosimilar candidates for the two mAbs were forcefully oxidized by H(2)O(2) for 24, 48 and …
In this study the middle-up approach is compared to the more expensive bottom-up analysis in a forced oxidation biosimilar comparabil …
Healthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease.
Si J, Chen L, Yu C, Guo Y, Sun D, Pang Y, Millwood IY, Walters RG, Yang L, Chen Y, Du H, Feng S, Yang X, Avery D, Chen J, Chen Z, Liang L, Li L, Lv J; China Kadoorie Biobank Collaborative Group. Si J, et al. Clin Epigenetics. 2023 Mar 28;15(1):52. doi: 10.1186/s13148-023-01464-2. Clin Epigenetics. 2023. PMID: 36978155 Free PMC article.
After adjustment for multiple risk factors of CHD and cell type proportion, compared with participants in the bottom quartile of deltaage, the OR (95% CI) for CHD was 1.84 (1.17, 2.89) for participants in the top quartile. ...
After adjustment for multiple risk factors of CHD and cell type proportion, compared with participants in the bottom quartile of delt …
Bottom-up modular synthesis of well-defined oligo(arylfuran)s.
Chen Y, Shen P, Cao T, Chen H, Zhao Z, Zhu S. Chen Y, et al. Nat Commun. 2021 Oct 25;12(1):6165. doi: 10.1038/s41467-021-26387-5. Nat Commun. 2021. PMID: 34697308 Free PMC article.
Oligofurans have attracted great attention in the field of materials over the last decades because of their several advantages, such as strong fluorescence, charge delocalization, and increased solubility. Although unsubstituted or alkyl-substituted oligofurans have been w …
Oligofurans have attracted great attention in the field of materials over the last decades because of their several advantages, such as stro …
Bottom-Up Analysis of Proteins by Peptide Mass Fingerprinting with tCITP-CZE-ESI-TOF MS After Tryptic Digest.
Segl M, Stutz H. Segl M, et al. Methods Mol Biol. 2022;2531:93-106. doi: 10.1007/978-1-0716-2493-7_7. Methods Mol Biol. 2022. PMID: 35941481
The following protocol portrays a bottom-up method, which was optimized for the application of CZE-ESI-TOF MS. ...Afterwards, disulfide bonds are reduced with tris-(2-carboxyethyl)phosphine (TCEP) and subsequently alkylated with iodoacetamide (IAA). The tryptic dige …
The following protocol portrays a bottom-up method, which was optimized for the application of CZE-ESI-TOF MS. ...Afterwards, disulfi …
Bottom-Up Design of Photoactive Chiral Covalent Organic Frameworks for Visible-Light-Driven Asymmetric Catalysis.
He T, Liu R, Wang S, On IKW, Wu Y, Xing Y, Yuan W, Guo J, Zhao Y. He T, et al. J Am Chem Soc. 2023 Aug 16;145(32):18015-18021. doi: 10.1021/jacs.3c05732. Epub 2023 Aug 8. J Am Chem Soc. 2023. PMID: 37551439
Photocatalytic asymmetric reactions based on CCOFs are eco-friendly and sustainable while they are still elaborate. In this work, we report a general bottom-up strategy to successfully synthesize several photoactive CCOFX (X = 1-5 and 1-Boc). ...The porphyrin units act as …
Photocatalytic asymmetric reactions based on CCOFs are eco-friendly and sustainable while they are still elaborate. In this work, we report …
Bottom-Up Synthesis of Covalent Organic Frameworks with Quasi-Three-Dimensional Integrated Architecture via Interlayer Cross-Linking.
Jin F, Wang T, Zheng H, Lin E, Zheng Y, Hao L, Wang T, Chen Y, Cheng P, Yu K, Zhang Z. Jin F, et al. J Am Chem Soc. 2023 Mar 22;145(11):6507-6515. doi: 10.1021/jacs.3c00550. Epub 2023 Mar 12. J Am Chem Soc. 2023. PMID: 36908113
Here, we rationally design and synthesize a class of cross-linked COFs ((C)COFs), in which the two-dimensional (2D) COF layers are anchored and connected by polyethylene glycol (PEG) or alkyl chains through covalent bonds. The bottom-up fabrication of these (C)COFs …
Here, we rationally design and synthesize a class of cross-linked COFs ((C)COFs), in which the two-dimensional (2D) COF layers are anchored …
Free-Standing Molecularly Thin Amorphous Silica Nanosheets.
Yamamoto E, Fujihara K, Takezaki Y, Ito K, Shi Y, Kobayashi M, Osada M. Yamamoto E, et al. Small. 2023 Jun;19(22):e2300022. doi: 10.1002/smll.202300022. Epub 2023 Feb 28. Small. 2023. PMID: 36855026
Here, this issue is addressed by using a new chemical protocol; solid-state surfactant lamellae with ordered alkyl-chain arrangements can serve as superior templates guiding free-standing amorphous silica nanosheets. ...
Here, this issue is addressed by using a new chemical protocol; solid-state surfactant lamellae with ordered alkyl-chain arrangements …
Tunable Cr4+ Molecular Color Centers.
Laorenza DW, Kairalapova A, Bayliss SL, Goldzak T, Greene SM, Weiss LR, Deb P, Mintun PJ, Collins KA, Awschalom DD, Berkelbach TC, Freedman DE. Laorenza DW, et al. J Am Chem Soc. 2021 Dec 22;143(50):21350-21363. doi: 10.1021/jacs.1c10145. Epub 2021 Nov 24. J Am Chem Soc. 2021. PMID: 34817994
The inherent atomistic precision of synthetic chemistry enables bottom-up structural control over quantum bits, or qubits, for quantum technologies. ...Here, we demonstrate that the electronic structure that enables optical-spin initialization and readout for S = 1, Cr(ary …
The inherent atomistic precision of synthetic chemistry enables bottom-up structural control over quantum bits, or qubits, for quantu …
Polygenic Risk and Chemotherapy-Related Subsequent Malignancies in Childhood Cancer Survivors: A Childhood Cancer Survivor Study and St Jude Lifetime Cohort Study Report.
Im C, Sharafeldin N, Yuan Y, Wang Z, Sapkota Y, Lu Z, Spector LG, Howell RM, Arnold MA, Hudson MM, Ness KK, Robison LL, Bhatia S, Armstrong GT, Neglia JP, Yasui Y, Turcotte LM. Im C, et al. J Clin Oncol. 2023 Sep 20;41(27):4381-4393. doi: 10.1200/JCO.23.00428. Epub 2023 Jul 17. J Clin Oncol. 2023. PMID: 37459583
An externally validated 179-variant polygenic risk score (PRS) associated with pleiotropic adult cancer risk from the UK Biobank Study (N > 400,000) was computed for each survivor. SMN cumulative incidence comparing top and bottom PRS quintiles was estimated, along with …
An externally validated 179-variant polygenic risk score (PRS) associated with pleiotropic adult cancer risk from the UK Biobank Study (N &g …
Proteome Analysis Using Gel-LC-MS/MS.
Goldman AR, Beer LA, Tang HY, Hembach P, Zayas-Bazan D, Speicher DW. Goldman AR, et al. Curr Protoc Protein Sci. 2019 Jun;96(1):e93. doi: 10.1002/cpps.93. Epub 2019 Jun 10. Curr Protoc Protein Sci. 2019. PMID: 31180188 Free PMC article.
After gel separation and staining/destaining, appropriate gel slices are excised, and in-gel reduction, alkylation, and protease digestion are performed. Digests are then processed for LC-MS/MS analysis. ...An optional strategy is to conduct in-solution reduction and al …
After gel separation and staining/destaining, appropriate gel slices are excised, and in-gel reduction, alkylation, and protease dige …
374 results